A.D. 1711 - Crossing the Atlantic Ocean, alchemists left their home countries heading for a new world. They obtained the "Immortal Drink" from a devil. Those who drank it became immortal, and can only be destroyed by being absorbed into another immortal's right hand.
1930s, New York - People living in the shadowy side of society, a boy named Firo and his partner, Miaza of the Martillo Family, a stupid thieving couple, Isaac and Miria, the three Gandor mafia brothers, a delinquent boy named Dallas and his sister Eve, the 200 year old alchemist Szilard and his assistant Ennis, lived unrelated lives until Szilard rediscovers the "Immortal Drink", and their fates become intertwined.
Aboard the Flying Pussy Foot, a transcontinental train from Chicago to New York, there are many kinds of people. For example, Goose and Chane of the terrorist group "Remlace", street gangs led by Jacuzzi and Nice, a murderer by the name of Ladd, and his fiancée Lua, Senator Beriam's wife and his daughter Mary, a delinquent boy, a conductor, an informer, etc. There are not only humans on the train, however… The legendary "Rail Tracer", a ghost who removes passengers from the back cars, also appears.
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